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Enzyme Replacement APIs are used in a medical treatment to replace an enzyme in patients in whom that particular enzyme is deficient or absent. Enzyme replacement drugs are currently available for some lysosomal diseases: Gaucher disease, Fabry disease, MPS I, [MPS II], MPS VI and Glycogen storage disease type II. Enzyme replacement drugs do not affect the underlying genetic defect, but increase the concentration of enzyme which the patient is deficient in.